Tietze Research Group
unveiling structure activity relationships of bioactive molecules

more information about us on 



Amid bond mimics - restraining the peptide backbone

development of conformation specific peptide backbone mimics based on 1,2,3-triazoles


Tietze et al., Chemistry, 2010

Tischler et al., Angewandte Chemie, 2012

Ion channels and toxins

Structure and binding of ion channel targeting cone snail toxins, development of efficient synthetic strategies for diffecult peptides


Kaufmann et al., Marine Drugs, 2019

Paul-George et al., Marine Drugs, 2019

Heimer et al., Analytical Chemistry, 2018


as part of the Mei Hong Lab (MIT):

Williams et al., JACS, 2013

Williams et al., JACS, 2016

G proteins

Analysis of G Protein motion by NMR & MD to unveil how G protein motion and signaling can be modified


Tietze et al., J Chem Inf Model, 2018

Reher et al., ChemMedChem, 2018

Schrage et al., Nature Communications, 2015


Superoxide Dismutases

NiSOD - unveiling the catalytic mechanism of superoxide degradation OR how nature tailors redox  properties of metalloproteins


Tietze et al., Chemistry, 2018

Tietze et al., Scientific Reports, 2017

Tietze et al., Angewandte Chemie, 2011



For our research we use state of the art NMR (solution and solid-state), molecular modelling (docking, MD simulation etc.) and synthetic techniques.