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WHAT WE DO
Amid bond mimics - restraining the peptide backbone
development of conformation specific peptide backbone mimics based on 1,2,3-triazoles
e.g.
Ion channels and toxins
Structure and binding of ion channel targeting cone snail toxins, development of efficient synthetic strategies for diffecult peptides
e.g.
Kaufmann et al., Marine Drugs, 2019
Paul-George et al., Marine Drugs, 2019
Heimer et al., Analytical Chemistry, 2018
as part of the Mei Hong Lab (MIT):
G proteins
Analysis of G Protein motion by NMR & MD to unveil how G protein motion and signaling can be modified
e.g.
Tietze et al., J Chem Inf Model, 2018
Reher et al., ChemMedChem, 2018
Schrage et al., Nature Communications, 2015
Superoxide Dismutases
NiSOD - unveiling the catalytic mechanism of superoxide degradation OR how nature tailors redox properties of metalloproteins
e.g.
Tietze et al., Chemistry, 2018
Tietze et al., Scientific Reports, 2017
Tietze et al., Angewandte Chemie, 2011
Techniques
For our research we use state of the art NMR (solution and solid-state), molecular modelling (docking, MD simulation etc.) and synthetic techniques.